DNA-binding Specificities of Cys₂His₂ Zinc Finger Proteins

For a given C₂H₂ zinc finger protein, we predict a position weight matrix representing its DNA binding specificity and display it as a sequence logo. This result can be used further to search genomic sequences for putative binding sites.

This site serves as an interface between a user's input and a set of prediction algorithms that are able to create the mentioned logos. It consists of a protein input screen, followed by the selection of the desired set of fingers, and the algorithm to be used. The results are delivered through a simple HTML page that contains the generated sequence logo.